The search for an HIV vaccine has taken a major step forward with the discovery of a potential Achilles heel of the virus that causes Aids.
Two powerful antibodies that attack a vulnerable spot common to many strains of HIV have been identified, improving the prospects for a vaccine against a virus that affects an estimated 33 million people and kills over 2 million each year.
The discovery is important because it highlights a potential way around HIV’s defences against the human immune system, which have so far thwarted efforts to make a workable vaccine. The hope is that a vaccine that stimulates the production of these antibodies could remain effective against HIV even as the virus mutates.
The monkeys that prove babies can be born to THREE parents… and may be the key to halting genetic illness
Scientists have produced four baby monkeys who each have three biological parents.
They used an IVF procedure designed to stop the spread of incurable inherited diseases.
Scientists believe the breakthrough could lead to the first genetically engineered children within a few years.
Revolutionary: Twins Mito and Tracker are two of the monkeys who were born using an IVF technique that creates babies with three biological parents. They were named after a dye called Mitotracker used in the procedure
It has provoked an ethical storm, however. Critics say it is a step towards an era of hybrid children and warn that it erodes the sanctity of life.
The technique is intended to help women who carry genetic diseases. It involves transferring healthy DNA from the mother’s egg cell into an egg donated by another woman.
Children conceived by the technique would inherit DNA from three sources - their mother, the donor and their father.
The American team who produced the macaque monkeys - named Mito, Tracker, Spindler and Spindy - say the technique could be used to eradicate potentially fatal forms of inherited epilepsy, blindness and heart disease.
The diseases, which affect some 150 UK babies a year, are caused by mutations in the mitochondrial DNA which is passed down from mothers to children.
Mitochondria are sausage- shaped ‘power packs’ that float around inside cells, converting food into energy that the body can use. Each contains a tiny
strand of DNA, carrying just 37 of the 20,000 or so human genes. The rest are in the DNA in the cell’s nucleus.
Spindler is another of the four monkeys who appear healthy after they were conceived using the new technique
Mitochondrial DNA can only be passed on via mothers’ eggs, not through sperm.
Doctors have identified around 50 diseases caused by mutations of this DNA - some of which kill before adulthood. Symptoms include muscle weakness, dementia, blindness, hearing loss and heart and kidney problems.
The U.S. experiment, reported today in the journal Nature, involved researchers at the Oregon National Primate Research Centre. They took an egg cell
from a mother carrying a mitochondrial disease and removed its nuclear DNA. This was then transferred into a second, healthy egg, whose own nuclear DNA had been removed.
The resulting ‘hybrid’ eggs contained nuclear DNA from the mother and fully-functioning mitochondrial DNA from the donor, and produced apparently healthy baby monkeys.
Such a process alters the DNA inherited by future generations, however - an idea that has long worried ethicists - although mitochondrial DNA affects only how cells convert food into energy, so children would inherit physical characteristics from their real mother’s nuclear DNA.
Josephine Quintavalle, of the campaign group Comment on Reproductive Ethics, said: ‘This is genetic engineering.
‘We should avoid at all costs interfering in the pattern of reproduction that has evolved
over millions of years. The objective is to stop mitochondrial diseases in the next generation - but it would be absurd if it unleashed something worse in generations to come.’
Stephen Green, director of pressure group Christian Voice, said he had concerns that scientists were going ‘too far, too fast’ and ‘playing God’.
He said: ‘These things are always done with the best of intentions but we have to think whether this will lead to any unintended consequences. When the child finds out they have two mummies, how will they feel?
‘We have to have a lot of sympathy for those with inherited conditions but we need to be very careful before we start interfering with nature.
‘There’s a thought that because scientists can do something they always want to do it and that’s not necessarily the right way’. But
Professor Sir Ian Wilmut, of the MRC Centre for Regenerative Medicine at Edinburgh University and leader of the team that cloned Dolly the sheep, said: ‘This demonstrates an exciting new route to therapy for diseases such as myopathy, in which muscle fibres do not function properly.
‘It also seems likely that mitochondrial malfunction predisposes patients to diseases such as osteoporosis, Alzheimer’s, Parkinson’s and stroke.’
Last year Newcastle University researchers created ten human embryos using a similar technique. They were destroyed after six days because current UK law says they cannot be kept longer than 14 days.
But the new Human Fertilisation and Embryology Act, which comes into effect on October 1, could open the door for a change in the rules.
Nobel prize-winning research discovered that impotence can be reversed or prevented with a natural health program. Impotence is almost always a physiological problem. It is very rarely psychological, “performance anxiety,” relationship difficulties, or “all in your head.” In the past, due to ignorance, many doctors promoted these beliefs. In fact, many medical articles about impotence, also called erectile dysfunction or ED, were published in psychiatric journals. A Nobel Prize winning discovery changed all that—and opened the door to natural solutions that may prevent, and even reverse, ED.
Impotence is Common
ED is a devastatingly common problem. An estimated 18-20 million American men have some degree of ED. That means nearly one in five men age 20 and older has some degree of impotence. If 20 percent of men having impotence is bad (and I think it is), it only gets worse as men age. In men age 70 and older, up to 70 percent—or seven out of ten have ED. [ii]
Such a high rate of ED is tragic because men and women both say that as they age, sex is still very important to their relationship. A recent AARP study of middle-aged and older adults found that five out of six people surveyed disagreed with the statement that “Sex is only for younger people.” Six out of 10 people stated that sexual activity was crucial to a good relationship. A Harvard University report on male sexuality after 50 says that 50-80 percent of healthy couples over age 70 report sexual activity on a regular basis, with half having weekly intercourse.[iii] Obviously, the desire to have sex doesn’t go away with age. It may not be the all-consuming drive you had when you were 20, but it doesn’t disappear
If it’s not psychological, then what causes the dramatic increase in impotence as men age? Is there anything you can do if you already have ED? What can you do to help prevent impotence from happening to you? Fortunately, thanks to scientific research, there are answers to these questions.
The 4 Most Common Causes of Impotence[iv] [v]
1. Damage to your network of arteries, veins and capillaries (vascular system) — 60%
2. Medications — 25%
(Please see “Men: Are Your Medications Making You Impotent” for vital information about the dangers of common meds.)
3. Decline in hormones — 5%
4. Other: alcohol, physical injury, bike riding, anxiety, depression, relationship difficulties — 10%
The Power of NO
Most men don’t want to hear “NO” in regards to sex. However, a gas called NO, or nitric oxide, is the answer to impotence. As you can see from the statistics above, the main cause of erectile dysfunction is a problem with the network of tubing that carries blood throughout your body—your vascular system.
The three men who won the Nobel Prize in 1998 identified precisely that not enough NO—nitric oxide—in your vascular system causes impotence. (Don’t confuse NO with nitrous oxide—laughing gas. They are not the same.)
Nitric oxide is mainly produced in the lining of your arteries, veins and capillaries. If the lining of these blood vessels is damaged, you won’t produce enough NO to keep your vascular system healthy—and you won’t be able to have an erection.
Most commonly, damage to your arteries is from inflammation and by oxidation of cholesterol. This causes lesions and plaque to form and arteries to become rigid and clogged. Rigid and clogged arteries prevent a healthy flow of blood and lead erectile dysfunction! Having enough NO can prevent or reverse the problem of impotetnce.[vi]
Here’s what the Nobel Prize announcement said…
“NO can initiate the erection of the penis
by dilating the blood vessels to the erectile bodies.”[vii]
A failure to produce enough NO causes failure of erections. It’s that simple. And it’s not just sexual function that suffers.
A lack of NO may lead to:[viii]
- Erectile dysfunction
- High blood pressure
- Heart attacks
- Plaque-filled arteries
- Low immune system
- Diabetic complications
- Memory loss
- Stomach ulcers
- Arthritis and other inflammatory conditions
The discovery of nitric oxide and its importance to the health of virtually every human organ was so revolutionary that it won the Nobel Prize in 1998!
What is NO?
Nitric oxide or NO is a gas that is mainly produced in the lining of your arteries, veins and capillaries. This lining, called the endothelium, is so delicate that it is only one cell thick! Anything that damages the endothelium endangers your ability to produce healthy amounts of NO. When you have a healthy and well-nourished endothelium, it produces optimum levels of NO.
NO is also produced by the nerve cells in the erectile tissue of the penis, and also by the nerves in the brain and the lungs. In order for the penile nerves to work properly and stimulate an erection, the blood vessels and the nerves must have enough NO to keep them in good working order.[ix]
The Viagra Revolution — The Good and the Bad
Viagra was developed based on the NO research. Viagra and other medications for ED influence the activity of NO in the penile area. These medications were a revolution in the treatment of impotence. Like many revolutions, it had a major pro and con. The pro was that many men were helped to have functional erections. The con was that there was a price to pay—side effects.
If you’re reading this article and you have ED, you may have tried the prescription medications and decided you want to use something long term that actually goes to the root of the problem—and avoids the side effects. The prescription medications don’t solve the problem of a lack of NO. Fortunately, there are safe, all-natural solutions that can increase your natural production of NO.
How You Can Get More NO
Unfortunately, you cannot take a direct supplement of nitric oxide. There are ways, however, to naturally increase your levels of NO. Eating the right foods and taking supplements may dramatically increase your levels of NO
5 Best Foods to Increase NO
Scientists are discovering that special antioxidants in food and beverages help the body produce healthy amounts of NO.
- Red wine, red wine extract and grapes are high in resveratrol and other flavonoids that increase nitric oxide.[x]
- High-flavanol cocoa and chocolate increase nitric oxide. Processing can reduce the flavanol content. All chocolate does not increase NO, so look for raw, unfermented cocoa or dark chocolate that guarantees a high flavanol content.[xi]
- Green and black tea are high in flavanol antioxidants that increase NO.
- Almonds are high in arginine, an amino acid that is a precursor to NO.
- Wild salmon and other high-protein seafood, eggs and meats are high in the amino acid, arginine, that is a precursor to NO. [xii]
6 Best Supplements that May Prevent or Reverse Erectile Dysfunction Caused by a Lack of NO
- Resveratrol — a powerful antioxidant that increases NO in arteries.[xiii] It helps make more NO available and significantly improves the relaxation of blood vessels, even where there is high blood pressure.[xiv] [xv] Resveratrol’s ability to increase nitric oxide has also been shown to help increase longevity.[xvi]
- Red wine extract (95% OPCs) and grape seed extract — specifically support health of blood vessels.[xvii]
- Alpha lipoic acid — powerful antioxidant that protects the endothelium.[xviii]
- L-Arginine – amino acid that is a precursor to NO.[xix]
- Boswellia — a potent natural herb that specifically protects arteries and the endothelium from inflammatory damage.[xx] [xxi]
- Herbal potency formula that contains: Tribulus, American ginseng, Cnidium, Epimedium, GABA. All of these natural herbs and supplements increase levels of NO. They work best when taken as a formula.[xxii]
ED=Early Detection of Heart Disease and Diabetes
One of the dangers of heart disease is that it is difficult to detect in its early stages. Half of all heart attacks happen to people with normal cholesterol. It’s hard for doctors to know how much inflammation and oxidation is damaging your arteries until it’s fairly well advanced. Now, scientists have discovered that erectile dysfunction is a very accurate early warning sign of heart disease.
A study at the University of Chicago revealed that ED was a more accurate predictor of significant heart disease than family history, cholesterol, or blood pressure levels. Dr. Parker Ward, M.D., lead author of the study said,”…the fact that heart disease and ED are linked biologically should come as no surprise.” [xxiii] The penile arteries are smaller than coronary arteries and so they will clog up from oxidized plaque sooner than heart arteries.
Damage to arteries and capillaries resulting in ED is a well-known side effect of diabetes. If you have diabetes, support healthy sexual functioning with a program to increase levels of NO.[xxiv]
Single Best Supplement to Help ED for Men with Peyronie’s
Peyronie’s is a curvature of the penis that may lead to erectile dysfunction. Fibrous tissue forms inside penile tissue that causes the penis to curve. Acetyl L-Carnitine has been shown to be one of the most effective treatments—more effective than prescription medication.[xxv] Please discuss the research findings with your doctor to determine the best program for you. Acetyl L-carnitine for Peyronie’s is taken at high dosages (2000 mg/daily) with food. Anti-inflammatory and antioxidant supplements may also be helpful in reducing the scarring that causes formation of the fibrous tissue.
|Scar size reduction||
DHEA Supplement May Help Improve Overall Sexual Function
Some men’s sexual difficulties are due to lower levels of hormones as they age. The data suggests that low hormones account for 5 percent of erectile difficulties. However, many men do not have trouble with erections, but have low sex drive and energy and reduced stamina and strength. Many men also have problems with depression and poor mood that can be helped with DHEA.
There is significant research that shows that oral or topical DHEA may help improve:
- Erectile dysfunction[xxvi]
- Mood and feelings of self-esteem[xxvii]
- Stamina, energy and performance[xxviii]
- Muscle mass and strength[xxix]
- Bone mass[xxx]
Two Sure Ways to Put Yourself at Risk for Impotence
For those of you who have read my book or other articles in Natural Health News Report you know that the scientific evidence points to two root causes of all chronic disease—including erectile dysfunction. They are inflammation and oxidation. If you are really serious about avoiding impotence as you age, I strongly suggest you read A Cardiologist’s Guide to Anti-Aging, Antioxidants and Resveratrol. It will give you more insight into the two root causes of erectile dysfunction, heart disease, diabetes and other chronic illnesses. It contains a step-by-step program to avoid inflammation and oxidation damage as you age. Aging does not have to be a time of weakness, sickness and loss of potency and vitality. By eating well, exercising and taking natural supplements, I believe you can live to a hundred—and still enjoy sex!
 Ignarro LJ. NO more heart disease. 2005. St. Martin’s Press: New York.
 Burnett Al, et al. American Heart Association Meeting Report: Erectile dysfunction’s heart risks may be offset by healthy lifestyle. Abstract P150(EP). Available from: www.americanheart.org.
 Harvard Medical School. Life after 50: A Harvard study of male sexuality. A healthy sex life—at any age! Harvard Health Publications. Available online from: www.health.harvard.edu.
 Viera AJ, et al. Newer pharmacologic alternatives for erectile dysfunction. Am Fam Phys. 1999 Sep 15; 60(4):1159-72.
 Uruology Channel. Erectile dysfunction. Available from: www.urologychannel.com/common/PrintPage.php
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 Hsieh T, et al. Resveratrol increases nitric oxide synthase. Cancer Res. 1999 June 1;59:2569-2601.
11 Hollenberg NK, et al. Cocoa, flavanols and cardiovascular risk. Br J Cardiol. 2004;11(5):379-86.
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 Hsieh T, et al. Resveratrol increases nitric oxide synthase. Cancer Res. 1999 June 1;59:2569-2601.
 Rush J, et al. Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Experim Biol and Med. 2007; 232:814-822.
 Shin S, et al. Trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo. Arch Pharm Res. 2008 Jan;31(1):83-7.
 Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.
 Maffei FR, et al. Free radical scavenging action and anti-enzyme activities of procyanidins from vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung. 1994 May;44(5):592-601.
 Ignarro (2005).
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 Gayathri B, et al. Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and mAP kinases. Int Immunopharmacol. 2007 Apr;7(4):473-82.
 Roy S. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells I sensitive to anti-inflammatory Boswellia. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60.
 Achike FI, et al. Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Clin Exp Pharmacol Physiol. 2003 Sep;30(9):605-15.
 Ward P, et al. Prediction of coronary artery disease by erectile dysfunction in men referred for nuclear stress testing. Arch Intern Med. 2006;166:201-6.
 Zheng H, et al. Lack of central nitric oxide triggers erectile dysfunction in diabetes. Am J Physiol. 2007 March.
 Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie’s disease: a preliminary report. BJU Int. Jul 2001;88(1):63-7.
 Reiter WJ, et al. Dehydroepiandrosterone in the treatment of erectile dysfunction in patients with different organic etiologies. Urol Res. 2001 Aug;29(4):278-81.
 Hunt PJ, et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison’s disease in a randomized, double-blind trial. J Clin Endocrinol Metab. 2000 Dec;85(12):4650-6.
 Morales AJ, et al. The effect of six months treatment with a 100 mg daily dose of DHEA on circulating sex steroids,body composition and muscle strength in age-advance men and women. Clin Endocrinol (Oxf). 1998 Oct;49(4):421-32.
 Morales (1998).
 Jankowski CM, et al. Effects of DHEA replacement therapy on bone mineral density in older adults: a randomized, controlled trial. J Clin Endocrinol Metab. 2006 Aug;91(8):2986-93.
NEWS – A recent study in a major nutritional journal notes a “remarkable increase in chronic kidney disease” plus a “remarkable increase in hypertension,” and dramatically rising rates of obesity and diabetes associated with the rise in fructose-filled foods and drinks. The authors present evidence that the unique ability of fructose (but not other sugars) to increase uric acid may be driving these increases. High levels of uric acid also increase risk of gout. See The Gout Report in this issue t for more information about how you can reduce your risk of gout and other uric-acid-related diseases.ACTION — If you must drink soda, consider switching to one made with cane sugar. (Diet sodas may also trigger health problems.) Switching to refreshing herb teas and water is an even better option. You can make your own healthy “soda” with a small amount of pure fruit juice or fruit juice concentrate and soda water. Check labels and avoid all drinks and foods made with fructose corn syrup.Johnson RJ, Segal, MS, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr. 2007:86:899-906Vitamin D3 May Extend Life Span by 5 Years!NEWS — The good news about the sunshine vitamin just keeps getting better. Mounting scientific evidence links higher daily intake (over 1,000 — 2,000 IU) of vitamin D3 with dramatically reduced levels of pain, inflammation, cancer, MS, and even colds and flus. Now, British and American researchers say it may extend your life by up to five years, based on the measurement of telomere length in over 2,000 female twin pairs.ACTION — Take a supplement of 1,000-2,000 IU of vitamin D3 (cholecalciferol) daily. Do not rely on vitamin D2 (eregocalciferol) in milk and most multivitamins. Supplements of vitamin D2 are not used by the body in the same way as sunshine and are four times less effective than vitamin D3. Fifteen minutes of sunshine a day (without sunscreen) provides your body with natural vitamin D3.
Richards JB, Valdes AM, et al. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr. 2007 Nov;86(5):1420-1425.
Coffee Lowers Risk of Gout 40%– Beer and Liquor Raise Risk, and Wine is Okay
NEWS — Researchers at Harvard Medical School and other institutions found compelling evidence that drinking four or more cups of coffee a day dramatically reduces the risk of gout for men. The risk of gout was 40 percent lower for men who drank 4 to 5 cups a day and 59 percent lower for men who drank 6 or more cups a day. Tea did not reduce risk of gout. The lead researcher, Dr. Choi, speculates that the mechanism of action may be the antioxidant action of phenol chlorogenic acid in coffee.
In a 2004 study, the same researchers found that beer and liquor raised serum uric acid levels, while moderate (1-2 glasses daily) wine drinking did not.
ACTION — If you have no health problems from drinking four cups of coffee a day — enjoy! (Avoid the new, sweetened coffee drinks. They have high levels of fructose.) If coffee gives you the jitters, prevents you from sleeping, or you just don’t like it, read the The Gout Report in this issue and discover easy, natural ways to lower your levels of uric acid—without drinking coffee!
Choi HK, Curhan G. Coffee consumption and risk of incident gout in men: a prospective study. Arthritis Rheum. 2007 Jun;56(6):2049-55.
Choi HK, Curhan G. Beer, liquor, and wine consumption and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2004 Dec 15;51(6):1023-9.
A recent study published in the American Journal of Pathology has found that the compound found in red wine known as resveratrol can stop out-of-control blood vessel growth in the eye. It’s a finding researchers say could have implications for preserving vision in some common blinding eye diseases such as diabetic retinopathy and age-related macular degeneration.
Conducting experiments in mouse retinas, researchers from Washington University School of Medicine in St. Louis found that resveratrol can inhibit angiogenesis, which is the formation of new blood vessels. When the mice were given resveratrol, they found that the abnormal blood vessels in their eyes began to disappear.
Researchers say because resveratrol is given orally, patients may prefer it to many current treatments for retinal disease, which involve eye injections. The compound also is easily absorbed in the body.
“This could potentially be a preventive therapy in high-risk patients,” said the study’s lead investigator, Rajendra Apte, M.D., Ph.D.
Resveratrol is one of the active, non-alcholic ingredients in red wine. It comes from the pulp of grapes used to make wine and has some of the highest levels of antioxidants found in nature.
Among its believed health benefits are increasing heart health, fighting cancer and delaying the aging process.
Drug-resistant TB is spreading across the world much faster than medical experts had feared, warned the World Health Organization on February 26, 2008. The Centers for Disease Control and Prevention (CDC) in the U.S. says the U.S. is likely to fall far short of its goal to eliminate TB as a public health problem.
ACTION: Take a vitamin D3 supplement daily. There is some good evidence that vitamin D3 raises your immunity to TB. One study gave healthy adults who had been exposed to TB a single, large oral dose of TB or a placebo. After six weeks, the researchers found that the vitamin D supplement significantly enhanced immunity to TB compared to placebo.
World Health Organization. New survey finds highest rates of drug-resistant TB to date. Available from: http://www.who.int/mediacentre/news/releases/2008/pr05/en/index.html
Bornman L, et al. Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study J Infect Dis. 2004 Nov 1;190(9):1631-41.
Martineau AR , et al A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med. July 15, 2007.
Breaking Anti-Aging News…
Experimental Alzheimer’s drug shows early promise!
Plus, Important Research Update on the “French Red Wine Paradox”
There’s some good news in the Anti-Aging battle.
There appears to be an exciting breakthrough with an experimental drug for Alzheimer’s disease.
I am thrilled to report to you that for the first time, there’s an experimental drug that is showing the promise of halting the progression of Alzheimer’s disease by taking a new approach: Breaking up the protein tangles that clog victims’ brains.
A new study released by Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, RKCSB, LRI, University of Leicester, Leicester LE2 7LX, United Kingdom indicate that daily doses of at least 0.5 g resveratrol were enough to produce an anticancer effect, and suggest that the drug may have potential as a chemopreventive agent. Researchers recruited 20 patients with resectable colon cancer who were scheduled to undergo surgical resection into the study. Ten patients were assigned to 0.5 g resveratrol prior for 8 days to resection and 10 were assigned to 1 g.Resveratrol sulfate glucuronide was a prominent metabolite in colorectal tissue of five patients assigned to the 0.5 g dose and nine patients assigned to the 1 g dose.In most cases, researchers said concentrations of resveratrol and its metabolic conjugates were higher in samples taken from the cecum, ascending colon and hepatic flexure/transverse colon compared with concentrations found in the splenic flexure, descending colon, sigmoid colon and rectum.The highest mean concentration of parent resveratrol was 18.9 nmol/g in the 0.5 g group and 674 nmol/g in the 1.0 g group, assuming 1 mL weighs 1 g, in normal tissue localized proximal to the tumor on the right side. In right-sided tumors, the highest mean concentration in the 8.33 nmol/g in the 0.5 g group and 94.1 nmol/g in the 1.0 g group.
Overall, tumor cell Ki-67 staining declined from 88.0% ± 6.64% in predose biopsy samples to 83.2% ± 10.0% in samples taken following surgery. When researchers analyzed the dosing groups separately, resveratrol decreased tumor cell Ki-67 staining by 5.6% in the 0.5 g group and 1.9% in the 1 g group, though the reduction was not considered significant.
A new study by the National Institutes of Health reveals that a key antioxidant contained in red wine, resveratrol may provide a defense against inherited breast cancer.
Investigators from the National Institutes of Health looked for the method by which mutations in tumor suppressor genes such as BRCA-1 lead to breast cancer. They found the normal form of BRCA-1 helps maintain the expression of a protein called SIRT1. SIRT1 in turn inhibits the expression of Survivin, an apoptosis inhibitor suspected of maintaining tumors and helping them grow. However, when BRCA-1 is mutated, SIRT1 levels drop, allowing Survivin to increase.
The researchers found resveratrol, a key component of red wine and grapes, strongly inhibits the growth of BRCA-1 mutant tumors in both cultured cells and animal models. The compound wards off the cancers by enhancing the activities of SIRT1, thus reducing the expression of the cancer booster, Survivin.
“Resveratrol may serve as an excellent compound for targeted therapy for BRCA1 associated breast cancers,” study author Dr. Chu-Xia Deng was quoted as saying.
SOURCE: Molecular Cell, published online October 9, 2008
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
Rui-Hong Wang,1 Yin Zheng,1 Hyun-Seok Kim,1 Xiaoling Xu,1 Liu Cao,1 Tyler Luhasen,1 Mi-Hye Lee,1 Cuiying Xiao,1 Athanassios Vassilopoulos,1 Weiping Chen,2 Kevin Gardner,3 Yan-Gao Man,5 Mien Chie Hung,6 Toren Finkel,4 and Chu-Xia Deng1,
1 Genetics of Development and
Diseases Branch, National Institute of Diabetes and Digestive and Kidney
Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD
2 Microarray Core Facility,
National Institute of Diabetes and Digestive and Kidney Diseases, National
Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
3 Laboratory of Receptor Biology
and Gene Expression, National Cancer Institute, National Institutes of
Health, 10 Center Drive, Bethesda, MD 20892, USA
4 Cardiology Branch, National
Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center
Drive, Bethesda, MD 20892, USA
5 Department of Gynecologic and
Breast Pathology, Armed Forces Institute of Pathology, Washington, DC
6 Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
The velocity of scientific breakthroughs is accelerating in literally all fields of study. The rapid growth in medical research should not be ignored. The day is fast approaching when the human life span will be substantially lengthened by breakthroughs in pharmacology. Instead of treating disease we will soon see major advancements in preventing disease. Another fascinating area of development will come from replacing worn out, diseased or otherwise damaged organs with organs that are literally grown in laboratories. This article appearing in the Times of London reads like a Philip K Dick novel. Perhaps real life is finally catching up with the science fiction on the 1950’s?
Huddled at the back of her shed, bleating under a magnificent winter coat and tearing cheerfully at a bale of hay, she is possibly the answer to Japan’s chronic national shortage of organ donors: a sheep with a revolutionary secret.
Guided by one of the animal’s lab-coated creators, the visitor’s hand is led to the creature’s underbelly and towards a spot in the middle under eight inches of greasy wool. Lurking there is a spare pancreas.
If the science that put it there can be pushed further forward, Japan may be spared an ethical and practical crisis that has split medical and political opinion.
As the sheep-based chimera organ technology stands at the moment, says the man who is pioneering it, the only viable destination for the pancreas underneath his sheep would be a diabetic chimpanzee.
Researchers in Boston found that living until you are a 100 isn’t all that hard. It’s not in your genes—it’s in your lifestyle. Avoiding obesity, inactivity, high blood pressure and not smoking were the keys to living a long and healthy life. A great deal of research points to a healthy diet high in antioxidants, grapes, berries, apples, vegetables and whole grains as the way to keep blood pressure normal and avoid obesity. Longevity researchers have found that the special polyphenols resveratrol and OPCs in red wine, red wine extract, grape skins, and seeds support healthy heart function and may extend lifespan. Recent research also found that one third of people still may live to 100 even with age-related diseases.
ACTION: Drink one glass of red wine daily or take a red wine extract high in OPCs from grape seed and skins, plus resveratrol. Eat a diet rich in fruits, vegetables, and whole grains. Exercise daily. Stop smoking.
Yates, L. Terry, D. Archives of Internal Medicine, Feb. 11, 2008; vol 168: pp 284-290, 277-283. News release, American Medical Association.
A cocktail of three flu viruses are reported to have mutated into a single pneumonic plague, which it is believed may be far more dangerous than swine flu. The death toll has reached 189 and more than 1 million people have been infected, most of them in the nine regions of Western Ukraine.
President of Ukraine Viktor Yushchenko has called in the World Health Organisation and a team of nine specialists are carrying out tests in Kiev and Lviv to identify the virus. Samples have been sent to London for analysis.
THE PROBLEM OF PAIN
The problem isn’t pain. The problem is pain that doesn’t go away. Pain is a natural signal from the body that there is something wrong. You stub your toe—pain! You sprain your ankle—pain! Inflammation is destroying cartilage in your knee—pain! Lack of circulation causes nerve damage in your feet—pain! When you are in pain, you are motivated to solve the problem. That’s good.
Unfortunately, there are problems that are not accompanied by pain. One of them is internal bleeding. Later in this article you’ll learn why NSAIDS pain medications are so dangerous. One of the reasons is that there’s often no pain signal to sound the alarm that you may be bleeding to death. That’s bad.
AP is reporting …
“Vets in the US state of Iowa said Wednesday that a household cat had tested positive for swine flu — the first known case in the world of the new pandemic strain spreading to the feline population.
“The domestic shorthair, a 13-year-old castrated male, apparently caught A(H1N1) off its owners — two of the three members of the family had previously contracted the deadly virus.
“This is the first cat that we are aware of with the pandemic H1N1,” said Brett Sponseller,an assistant professor of veterinarian microbiology who helped treat the pet at Iowa State University’s College of Veterinary Medicine.”
We hope this is some sort of hoax…
To read the complete article go to …
NATURAL SOLUTIONS TO END YOUR PAIN
TWO KINDS OF CHRONIC PAIN
There are two main types of chronic pain. One is continuing pain that is clearly associated with a known physical problem. Arthritis, or pain in joints, is an example of chronic pain that is connected to a known physical problem.
The second type of chronic pain is pain that is not associated with a clear physical cause—the “nothing wrong” kind of chronic pain. Lower back pain is frequently in this category. All-over bodily pain (musculoskeletal pain) is another type of agonizing pain without apparent cause that doctors frequently dismiss, misdiagnose and mistreat. These kinds of pain can be extremely frustrating for doctors and patients. You know you’re in pain, but doctors can find “nothing wrong.” Fortunately, the latest research discoveries reveal there are real causes and natural solutions to these kinds of pain.
In this article you will learn about the latest research on safe, effective solutions to both kinds of chronic pain. One of the most exciting discoveries in recent years is the powerful effect of natural vitamin D3—the sunshine vitamin—on pain. Knowledge about vitamin D3 is one of the most important scientific breakthroughs of the decade and my personal top health story for 2007. For complete news about vitamin D3, look for the full report in the next issue of Natural Health News Report. Boswellia serrata is another natural solution to inflammation and pain with powerful new research to back up its effectiveness.
You have a greater risk of dying if you have a heart attack in December than any other month of the year. Why? Doctors don’t know. Researchers found that December heart attack patients had the same standard of care—but more died. Protecting your heart—in December and throughout the year—is the single most important thing you can do to stay alive and well. This special report will give you the latest news on how you can improve your chances of surviving a heart attack—in good shape.
Heart disease is the number one killer of both men and women. In fact, more women than men die from heart attacks. Unfortunately, they may also get worse care from their doctors. Less than half the doctors in a survey even considered heart disease a threat to their women patients! Since they don’t think it’s a problem, many doctors don’t talk to their women patients about how to recognize and respond to heart attacks. So women—pay especial attention to this report. You are at greater risk.
The Truth About Heart Attacks
For many years, doctors and scientists believed that arteries got narrow from eating foods high in cholesterol and this caused heart attacks. You eat too many steaks and buttered baked potatoes, cholesterol builds up, the artery gets too narrow for blood to flow through, and bang! You have a heart attack. Now, scientists have discovered that it’s not that simple.
- Half of all heart attacks happen in people with normal levels of cholesterol.
- Only 14% of heart attacks occur where the artery is the narrowest.Most heart attacks occur in fairly clear locations of the artery.
- Damage to arteries by oxidizedcholesterol and inflammation triggers the process that leads to heart attacks.
- Most heart attacks are caused by a piece of inflamed or “vulnerable” plaque that suddenly ruptures, forms a clot, and blocks circulation to the heart.
- Standard testing by angiography and stress testing cannot detect vulnerable plaque.
- You may not know it’s coming. Sixty-four percent of women and 50% of men who die suddenly of heart disease have no previous symptoms.
A shocking report was published in the prestigious Journal of Urology in May, 2006. Middle-aged and older men who take aspirin, ibuprofen (Advil, Motrin IB), or naproxen (Aleve) have twice the risk for impotence as men who don’t! The researchers concluded that the use of NSAIDs increased the risk of erectile dysfunction. The study estimated that nearly 17% of erectile dysfunction could be due to the use of NSAIDs. The researchers proposed that the NSAIDs may block the body’s release of nitric oxide, a natural body chemical needed to achieve erections.[i]
5 Worst Medications for Healthy Male Sexual Function[ii] [iii]
2. Blood pressure medications, especially beta blockers and diuretics
4. Anti-anxiety medications
Caution: Do not discontinue any medications without first consulting with your physician. There may be alternatives, both natural and pharmaceutical, that can replace them under your doctor’s supervision. For example, a recent study found that almost all anti-depressants were no more effective than a placebo.[iv] Alternatives such as St. John’s Wort may help depression as well, or better, without the side effects.[v] However, withdrawal from prescription anti-depressants must be done under your doctor’s care as there may be severe side effects.
Prevent Pain Without Impotence
If you are in pain, you probably reach for a bottle of aspirin or Advil. Who would ever have thought that common over-the-counter pain pills could cause impotence? Fortunately, there are natural alternatives that may be just as effective—without the side effects of impotence and GI bleeding. If you are taking NSAIDs for arthritis or other pain and inflammation, consider taking a natural alternative such as boswellia, turmeric, hops extract, ginger, vitamin D3 or a formula that combines several of these natural pain and inflammation relievers. Scientific research has shown that they can be as potent as NSAIDs, without the dangerous side effects.
Boswellia, for example, has been shown to be as effective as an NSAID for osteoarthritis in the knee. It is a potent anti-inflammatory.[vi]
[i] Shiri R, et al. Effect of nonsteroidal anti-inflammatory drug use on the incidence of erectile dysfunction J Urol. 2006 May;175(5):1812-16.
[ii] Viera AJ, et al. Newer pharmacologic alternatives for erectile dysfunction. Am Fam Phys. 1999 Sep 15: (60)4.
[iii] Shiri (2006).
[iv] Kirsch I, et al. Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration. PLoS Medicine Vol. 5, No. 2, e45.
Published online: February 26, 2008. doi:10.1371/journal.pmed.0050045 Available from: http://medicine.plosjournals.org/perlserv/?request=get- doi
[v] Kirsch I. St Johns wort, conventional medication, and placebo: an egregious double standard. Complementary Therapies in Medicine, Volume 11, Issue 3, Pages 193-195.
[vi] Sontakke S, et al. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of the knee. Indian J Pharmacol. 2007;39(1):27-29.
How did a humble vitamin that can be obtained free from sunshine make Time Magazine’s Top 10 Medical Breakthroughs for 2007? The other nine medical breakthroughs were all high-tech medications, vaccines and medical equipment. Vitamin D is about as low tech as you can get. It’s natural, it’s free, it comes from sunshine and it’s been known for over a hundred years. What’s so important about it now?
The First Vitamin D Deficiency Epidemic–Rickets
Vitamin D was identified in the early 20th century as an essential requirement of normal bone development. For several hundred years, children who lived in cities in northern Europe had been plagued by a devastating bone disease called rickets. Lack of sunshine as the cause was suspected as early as 1822. It was also noticed that children along the coastlines who were given a daily dose of cod liver oil did not develop the disease.
By the beginning of the 20th century, more than 80% of children living in industrialized cities in North America and Europe suffered from rickets. In 1921, two doctors in New York City demonstrated that sunlight could cure rickets when they exposed sick children to sunlight on the roof of a New York City hospital. Soon after that a way was found to fortify milk with vitamin D and this helped eradicate rickets in the United States.
Scientists now know that when human skin is exposed to sunlight, it creates a natural compound called cholecalciferol—a form of vitamin D called D3. Almost every cell in your body must have vitamin D3 to stay healthy. Not enough vitamin D3 and you’re going to have problems. Lots of problems in lots of cells.
According to a new study conducted by Chun Chao, Ph.D., a research scientist at Kaiser Permanente in the October issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, an antioxidant contained in red wine called resveratrol may provide protection against lung cancer, told DOTmed News.
Dr. Chao reports that her study looked at demographic and lifestyle data from 84,170 Kaiser members aged 45 to 69, who were enrolled in Kaiser’s California Men’s Study between 2000 and 2003. The study identified 210 cases of lung cancer. As part of the study Dr. Chao measured the effect of beer, red wine, white wine and liquor consumption on the risk of lung cancer. Her research found there was a 2 percent lower lung cancer risk associated with each glass of red wine consumed per month, while there was no benefit noted for consumption of white wine, beer or liquor.
According to Dr. Chao’s research the most substantial risk reduction was indicated among smokers who drank one to two glasses of red wine per day. In percentage terms Chao’s study revealed a 60 percent reduction in lung cancer risk in the men included in the study. The study also revealed that men who smoke increased their risk of lung cancer by 10 percent, while red wine’s protective benefit for those in this group is roughly half that of non smokers.
Dr. Chao’s study is another step in proving the health benefits of resveratrol and its potential as a powerful cancer fighter.
Recent studies on mice that were given resveratrol supplements, showed the compound retarded lung cancer growth and also induced lung cancer cells to commit apoptosis. Apoptosis refers to cancer cells that are induced to self-destruct. The new biological drugs, like Velcade for multiple myeloma, are being engineered to perform this critical function.
Dr. Chao, says she’ll be looking at how drinking red wine affects prostate, colorectal and perhaps bladder cancer in upcoming studies.
This story was posted by the Times of London. We think it is so interesting we highly recommend reading it…
There is a magnet that can detect malaria at the flick of a switch, a flu-resistant chicken, an “antiviral” tomato and a vaccine enhanced with the use of a laser. The ideas are so bold that, as the scientists behind them admit, they can often struggle for funding.
Today, though, more than 80 projects at the far edge of innovation in global health research will share millions of pounds of grants to support unorthodox thinking — and the outside chance of a world-changing discovery.
Among the recipients, announced today by the Bill and Melinda Gates Foundation as part of their Grand Challenges initiative, are three British scientific teams pursuing novel approaches to prevent and treat infectious diseases such as tuberculosis, malaria and pneumonia, as well as viruses such as HIV.
Many men who take the “new-generation” of antidepressants like Prozac (SSRIs) know first hand that they lower libido and increase impotence. Yet, that’s what their doctor told them to take for depression. And they felt better, so they kept taking them—even though there were serious side effects like impotence and loss of sex drive. Now, researchers who were able to review research trials that were never published by the pharmaceutical companies say that people feel just as good on placebo as they do on Prozac.
Forty million people take Prozac and other similar drugs to beat the blues. They spend tens of billions of dollars for relief from depression. The latest research shows that placebo pills worked just as well. Dr. I. Kirsch and his research team had access to data that had not been previously published by requesting all trials through the Freedom of Information Act.
Dr. Kirsch, the lead author of the review, says, “Given these results, there seems little reason to prescribe antidepressant medication to any but the most severely depressed patients, unless alternative treatments have failed.”
Is it really possible to prevent heart disease and other devastating chronic illnesses as you age—without medication and surgery? Dr. William Gruss, M.D., a practicing cardiologist, says it is—and he cites over 200 published research papers to prove it in his new book A Cardiologist’s Guide to Anti-Aging, Antioxidants & Resveratrol.
In the book, Dr. Gruss explains how to reduce risk your risk of dying from heart disease by 40%, reduce your risk of cancer by up to 77%, reduce your risk of Alzheimer’s, diabetes and other chronic diseases and how you may even extend your lifespan. He explains in easy-to-understand language the real causes of chronic illness and what you can do to avoid them.
“Most practicing physicians don’t have the time to do this kind of research,” says Dr. Gruss. “I wrote this book to help people live a longer, healthier life—and also to inform their doctors about the cutting-edge research on anti-aging and chronic illness.”
Dr. Gruss is concerned that although research scientists have proven the connection between inflammation and oxidation and chronic diseases, many doctors aren’t getting the message. “Once you realize that all chronic diseases are caused by the same two things—oxidation and inflammation—you can start to do something about it,” says Dr. Gruss. (See The Gout Report in this issue.) What Dr. Gruss suggests you do is take a combination of five natural “super” supplements combined with some simple lifestyle changes.
One of the “super” supplements that Dr. Gruss recommends is resveratrol. Resveratrol, a compound found in red wine, red wine extract, grapes and a few other plants, has been in the news recently as an anti-aging “miracle.” Dr. Gruss thoroughly reviews the scientific literature on resveratrol and uncovers some astonishing research that has not yet hit the headlines.
“The work at Harvard on anti-aging and resveratrol is certainly exciting,” says Dr. Gruss. “However, as a cardiologist, I am equally excited about the use of resveratrol to prevent damage from heart attacks and strokes. Believe me, your doctor is not going to hear about this from the pharmaceutical companies.”
One of the most startling “secrets” revealed by Dr. Gruss in the book is the use of the antioxidant supplement alpha lipoic acid to successfully treat diabetic neuropathy. “The scientific evidence strongly supports the use of this natural supplement to help reduce the pain and numbness suffered by many diabetics,” he states.
Another highlight of the book is Dr. Gruss’s natural approach to reducing the risk of cancer. “People are so afraid of cancer they become apathetic. They think there’s nothing they can do to prevent it. Fortunately, that’s not true. You can reduce your risk of cancer significantly by a few simple lifestyle changes and the right natural supplements.”
“I don’t believe there is another book on the market like this,” concludes Dr. Gruss. “It presents the truth about what is really causing our epidemic of chronic diseases—and what you can do about it. There are very strong economic interests that do not want this information published and may attack me and the book. However, I am confident in the scientific evidence I present. As a physician, I believe my first duty is to help people be healthy.”
A Cardiologist’s Guide to Anti-Aging, Antioxidants and Resveratrol is available from http://www.naturalhealthnewsreport.com/ or call 1-800-917-8914 (Florida residents call 1-561-750-4133) to place your order now.
Scientists at New York’s Mount Sinai School of Medicine this past week unveiled lab-made human antibodies that can disable several types of influenza, including highly-lethal H5N1 bird flu and the “Spanish Flu” strain that killed tens of millions in 1918.
Tested in mice, the antibodies work by binding to a previously obscure structure in the flu virus which, when blocked, sabotages the pathogen’s ability to enter the cell it is trying to infect, according to the study.
Because this structure — described by one scientist as a “viral Achilles’ heel” — is genetically stable and has resisted mutation over time, the antibodies are effective against many different strains.
The breakthrough “holds considerable promise for further development into a medical tool to treat and prevent seasonal as well as pandemic influenza,” said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, which helped fund the study.
Researchers in Finland found that men who use NSAIDS such as aspirin, ibuprofen and naproxen had twice as much erectile dysfunction as men who did not use NSAIDs. The authors estimate that NSAIDs could be linked to nearly 17% of all erectile dysfunction. (See article “Men: Are Your Medications Making You Impotent?”)
ACTION — Avoid NSAIDs and use natural anti-inflammatory and pain supplements such as boswellia, ginger, turmeric, vitamin D3, hops extract. Change your diet to include more anti-inflammatory foods such as salmon, olive oil and fresh fruits and vegetables. Reduce your risk of erectile dysfunction by supporting healthy vascular health with resveratrol, red wine extract, grape seed extract and other antioxidants. Caution: If you have been prescribed aspirin for heart disease, discuss with your doctor before stopping aspirin.
Shiri R, et al. Effect of nonsteroidal anti-inflammatory drug use on the incidence of erectile dysfunction J Urol. 2006 May;175(5):1812-16.
LONDON – Health experts say extraordinary measures against swine flu — most notably quarantines imposed by China, where entire planeloads of passengers were isolated if one traveler had symptoms — have failed to contain the disease.
Despite initially declaring success, Beijing now acknowledges its swine flu outbreak is much larger than official numbers show.
According to tests prompted by Associated Press the number of people drinking water that’s been contaminated with trace amounts of drugs increased by 41 million people from AP’s last story on the situation this past March. The news service has been reporting there’s a potentially dangerous presence of pharmaceuticals in the nation’s reservoirs.
The AP stories on the tainted drinking water prompted both federal and local legislative hearings, which yielded by partisan calls for mandatory testing and disclosure. The substantial interest the AP stories generated also led officials in at least 27 additional metropolitan areas to analyze their drinking water. More than half, 17 cases of water proving positive for contamination from pharmaceuticals well known points of origin like Reno, Nev., Savannah, Ga., Colorado Springs, Colo., and Huntsville, Ala. Results are for still pending for three of the metropolitan location.
The increase in the number of known to be exposed to drug-contaminated drinking water supplies has grown dramatically simply because testing has finally to increase. Experts widely believe the actual number of Americans drinking tainted water to be much higher than 46 million.
There is no doubt about it. The Anti-aging Antioxidant Revolution has already begun and is gaining momentum as more and more scientific evidence comes forth. We have catapulted past the days of just taking vitamin and mineral supplements and are now dealing with exciting natural antioxidant compounds. When used in the right combination – synergistically – they can provide greater health benefits than when used alone. The sum of the parts may just be greater than the whole!
Recently, the remarkable news about Resveratrol, found in red wine, created such interest that nearly everyone has had to repeat the name out loud just so they are saying it properly. Examples of its benefits are as follows:
1. Improves the number, health, and function of the mitochondria, the tiny structures inside almost every cell that produces 95% of our energy.
2. Helps provide cardiovascular protection against damage from heart attacks and stroke.
3. May extend life span. Activation of the anti-aging Sirtuin gene.
4. Reduces oxidation of LDL-cholesterol (“bad” cholesterol) that leads to atherosclerotic plaque formation in the arteries.
5. Reduces blood clotting from platelet aggregation.
6. Increases stamina.
7. Helps to clear the type of plague that can cause Alzheimer’s.
8. Protects skin from UV (Ultraviolet radiation) damage.
9. Stimulates nitric oxide that supports healthy blood vessels.
Good news on the swine flu. Mexican officials lowered their swine flu alert level in the capital today and are allowing cafes, museums and libraries to reopen this week, even as WHO (world health) officials weighed raising their pandemic alert to the second highest level this past week.
Mexican health officials declared the epidemic to be waning at its epicenter, announcing this coming Wednesday will conclude a five-day closure of nonessential businesses. They’ve credited the reducing the spread of the new flu virus with this closure so allowing commerce to resume appears to be a good sign.
It’s important to how ever note that Mexican health authorities haven’t decided when to reopen schools across their country and are insisting that inspections are necessary before students can return to class.
Meanwhile World Health Organization officials as well as health officials across the globe remain vigilant insisting the swine outbreak’s spread around the world remains in its early stages, but there were no imminent plans to raise the pandemic alert level from the level 5 it is currently set at.
Finally a cure for the common cold: Remarkable discovery in a Cambridge laboratory may change immunology science forever
In a dramatic breakthrough that could affect millions of lives, scientists have been able to show for the first time that the body’s immune defenses can destroy the common cold virus after it has actually invaded the inner sanctum of a human cell, a feat that was believed until now to be impossible.
The discovery opens the door to the development of a new class of antiviral drugs that work by enhancing this natural virus-killing machinery of the cell. Scientists believe the first clinical trials of new drugs based on the findings could begin within two to five years.
The researchers said that many other viruses responsible for a range of diseases could also be targeted by the new approach. They include the norovirus, which causes winter vomiting, and rotavirus, which results in severe diarrhea and kills thousands of children in developing countries.
To read further….
Medical research isn’t perfect. Government regulatory agencies aren’t either. Unfortunately, the combination of poor research plus a government agency’s failure to correct the researchers’ errors resulted in one of the biggest public health disasters in modern history. The mistake? Believing that taking adequate amounts of vitamin D3 is dangerous. The consequences? Millions of Americans are deficient in vitamin D3. How important is that? Very, very important.
Breast Cancer Reduced Up To 77%
with Higher Levels of Vitamin D3
A recently published four-year, double-blind, randomized placebo-controlled trial—the “gold standard” of clinical trials—studied over 1,000 postmenopausal women in Nebraska. The researchers found that women who received 1100 IU of vitamin D3 during the entire four-year period had 60% less breast cancer than the placebo group who took no vitamin D3. When the first year was “washed-out” due to the chance of some women already having breast cancer, the reduction in breast cancer was an amazing 77%![i] (The women also received 1500 mg calcium. Calcium alone had no effect on cancer.) I know of nothing else that has this kind of “gold standard” proof in preventing breast cancer—safely and economically. The dose of 1100 IU of vitamin D3 was almost three times what the government agency recommends.
To fully understand how this could affect you and your family, let me explain the statistics of this. First, one out of three Americans will be diagnosed with cancer. So, you or a loved one has a very good chance of getting cancer. According to this study, if you line up 100 women who would have gotten breast cancer— and they are all taking 1100 IU of vitamin D3—77 of these women who would have gotten breast cancer won’t.
BRONX, NY – Researchers at Albert Einstein College of Medicine of Yeshiva University have linked resveratrol, a chemical compound found in red wine, to improved health of patients with impaired glucose tolerance (IGT), also known as “pre-diabetes.”
The results of the small pilot study presented at the annual meeting of the American Diabetes Association (ADA) earlier this month showed promise. Among 10 patients with IGT given resveratrol supplements at concentrations higher than those normally found in wine, grapes or peanuts, all demonstrated lower post-meal glucose levels and improved insulin sensitivity – an encouraging outcome with potential implications for those with type 2 diabetes or at high risk for the condition. The study was led by Jill Crandall, M.D., associate professor of clinical medicine and director of the Diabetes Clinical Trials Unit at Einstein.
“The results of this pilot study are preliminary and need to be confirmed in larger numbers of patients,” said Dr. Crandall. “However, we are encouraged by these findings and plan to conduct additional studies to further explore the potential utility of resveratrol in improving glucose metabolism”
Also presented at the meeting was a related study by Meredith Hawkins, M.D., professor of medicine and director of the Global Diabetes Initiative at Einstein. She reported on the effect of resveratrol in overweight, middle-aged subjects who were insulin resistant. Using a highly sensitive measurement technique, Dr. Hawkins detected a 40 percent increase in insulin sensitivity, as well as improvements in mitochondrial function. An unrelated, non-Einstein resveratrol study presented at the ADA meeting showed the substance may prevent harmful blood vessel growth in the retina of mice.
- VITAMIN D3 REDUCES RISK OF CANCER 77%
Observational studies had revealed that reducing our exposure to the sunshine vitamin—vitamin D—increased risk of cancer. Now a human intervention trial of over 1,000 postmenopausal women reported in the June 8, 2007, online edition of the American Journal of Clinical Nutrition that women who took at least 1,000 IU of vitamin D3 and 1,500 mg of calcium daily for four years had a 60% reduction in breast cancer. Calcium alone had no effect on cancer. If the first year was washed out (to account for women who already had cancer) the reduction of risk was an astonishing 77%. That means that out of 100 women who would have gotten cancer, 77 won’t. Researchers said the study was applicable to other forms of cancer. If every person in America took at least 1000 IU of vitamin D3….the implications are enormous.
Action: Take at least 1,000 IU of vitamin D3 daily for life. Start now. Look for a full report on vitamin D3 in next month’s issue of Natural Health News Report.
- MRSA SUPERBUG KILLS MORE PEOPLE THAN AIDS
Methicillin resistant staphylococcus aureus has been the scourge of hospitals for years and now a different and even deadlier strain is out in the community causing flesh- eating skin infections and death. A study published in the October, 2007, Journal of the American Medical Association found MRSA causing nearly 100,000 infections and about 19,000 deaths—more than died from AIDS.
Action: Wash your hands frequently. Don’t share personal items such as razors. If you are infected, consider alternative therapies such as topical essential oils and French clay in addition to prescription medication. Take natural remedies to support your immune system and prevent infection.
- ANTIBIOTICS FAIL SINUS SUFFERERS
Perhaps this is not news to you after several rounds of antibiotics that didn’t help your sinus infection. A new study published in the December, 2007, Journal of the American Medical found that antibiotics work no better against sinus infections than a placebo. In addition, antibiotics may cause harm by increasing your resistance to medications. Nasal steroid spray also had the same results as a placebo. Antibiotics were recently found to be ineffective against ear infections and bronchitis as well.
Action: Use natural remedies that clear sinus infections.
- ANTI-AGING ADVANCES WITH ALPHA LIPOIC ACID
Alpha lipoic acid turns on the basic cellular defenses of the body, including some that naurally decline with age. It restores glutathione, a powerful cellular antioxidant, and acts as a powerful anti-aging agent, reports researchers at Oregon State University in May, 2007.
Action: Take alpha lipoic acid supplement.
- FRUCTOSE CORN SYRUP IN SODAS AND FOOD IMPLICATED IN CHRONIC DISEASES AND OBESITY
The American Journal of Clinical Nutrition published evidence in the October, 2007, issue that fructose increases obesity, uric acid, kidney disease, heart disease, diabetes, metabolic syndrome and other chronic diseases. Our livers do not metabolize high fructose levels well.
Action: Stop drinking sodas and eating foods with high fructose corn syrup.
TOP BOOK OF 2007
Why Too Much Medicine is Making Us Sicker and Poorer
By Shannon Brownlee.
TOP HEALTH STORY TO WATCH IN 2008
Growing public awareness of the dangers of over-the-counter and prescription medications and the unhealthy influence of drug companies over university research, peer-reviewed medical journals and the FDA.
I don’t know about you but as far as I’m concerned the persistent reports by researchers about the low quality standards followed by bottled water companies really gets under my skin. In a day and age where a small bottle of water can cost as much as $2 out of a vending machine or convenience store you would think the water would be at least be pure. Apparently this isn’t the case.
According to study released this week by an environmental advocacy group water tested leading brands of bottled water turned up a variety of contaminants often found in ordinary tap water.
These findings of course make a mockery of the advertising claims by bottled water companies and challenge the popular impression that bottled water is purer than tap water, the researchers say. While, all the brands tested in this study met federal health standards for drinking water, two brands did violate a California state standard, according to the study.
A bottled water industry group International Bottled Water Association of course immediately branded the findings “alarmist.” According to the associations President Joe Doss said the study is based on the faulty premise that a contaminant is a health concern “even if it does not exceed the established regulatory limit or no standard has been set.”
Lousy argument as far as most people paying up to $2 a bottle would retort. Especially when you look closely at the results of the lab tests on 10 brands of bottled water detected 38 chemicals including bacteria, caffeine, the pain reliever acetaminophen, fertilizer, solvents, plastic-making chemicals and the radioactive element strontium. Though some probably came from tap water that some companies use for their bottled water, other contaminants probably leached from plastic bottles, according to the researchers who prepared this latest study.
“In some cases, it appears bottled water is no less polluted than tap water and, at 1,900 times the cost, consumers should expect better,” said Jane Houlihan, an environmental engineer who co-authored the study.
The Washington-based Environmental Working Group, an organization founded by scientists that advocates stricter regulation conducted the study over 2 years. The study concludes the contaminants in bottled water purchased in nine states and Washington, D.C.
Of the 10 brands tested by Researchers, eight did not have contaminants high enough to warrant further testing. But two brands did, so more tests were done and those revealed chlorine byproducts above California’s standard. The researchers identified those two brands as Sam’s Choice sold by Wal-Mart and Acadia of Giant Food supermarkets.
In the Wal-Mart and Giant Food bottled water, the highest concentration of chlorine byproducts, known as trihalomethanes, was over 35 parts per billion. California’s limit is 10 parts per billion or less, and the industry’s International Bottled Water Association makes 10 its voluntary guideline. The federal limit is 80.
Wal-Mart insists its own studies did not turn up illegal levels of contaminants. Giant Food officials released a statement asserting that Acadia meets all regulatory standards. Acadia is sold in the mid-Atlantic states, so it isn’t held to California’s standard. In most places, bottled water must meet roughly the same federal standards as tap water.
The researchers also said the Wal-Mart brand was five times California’s limit for one particular chlorine byproduct, bromodichloromethane. The environmental group wants Wal-Mart to label its bottles in California with a warning because the chlorine-based contaminants have been linked with cancer. It has filed a notice of intent to sue.
Wal-Mart spokeswoman Shannon Frederick said the company was “puzzled” by the findings because testing by suppliers and another lab had detected no “reportable amounts” of such contaminants. She said Wal-Mart would investigate further but defended the quality of its bottled water.
The researchers recommend that people worried about water contaminants drink tap water with a carbon filter.
NEWS — German researchers discovered that heart attacks, cardiac arrests, episodes of irregular heartbeat and activation of implanted defibrillators can triple for people watching major sports events such as world soccer and the Super Bowl.
ACTION – Drink red wine, nibble on grapes or take a supplement high in resveratrol before you start eating. Avoid high-fat snacks. Resveratrol is known to help prevent damage from heart attacks in laboratory animals. If you have a heart condition, keep aspirin and medications handy. Chew an aspirin if you suspect you are having a heart attack and don’t delay getting to the hospital in order to watch the game. They probably have TV in the emergency room.
Gruss, W. A Cardiologist’s Guide to Anti-Aging, Antioxidants, and Resveratrol. Renaissance Education: Boca Raton, FL. 2007.
Wilbert-Lampen U, et al. Cardiovascular Events during World Cup Soccer. N Engl J Med 2008 358: 475-483.
STUDIES NEVER PUBLISHED
NEWS—The New England Journal of Medicine published a study showing that nearly a third of antidepressant drug studies are never published and nearly all of them showed that the anti-depressant didn’t work. In studies that were published, results were rewritten to make the drug seem more effective than it really is. He found that 37 out of 38 positive studies were published.
ACTION—If you are taking antidepressant medications, ask your doctor about this article. Some types of antidepressants are much more effective than others. Ask your doctor about some of the natural therapies for depression, including sunshine, vitamin D3, and other supplements.
Turner EH, et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 358:252, January 17, 2008.
SUNSCREENS CAN BE HARMFUL TO SKIN
NEWS — A research team led by chemists at the University of California, Riverside, found that sunscreen chemicals can cause oxidative damage to skin if not used correctly. After a short period of time, sunscreen chemicals are absorbed into the skin allowing UV radiation to oxidize surface skin molecules. Other researchers are exploring the use of natural antioxidants such as resveratrol to prevent skin damage. See future issues of Natural Health News Report for more news about antioxidant skin protection.
ACTION — If you are going to be out in the sun for long periods of time, cover up with clothing or reapply sunscreen at least every two hours. Taking an anti-oxidant, anti-inflammatory dietary supplement may help reduce skin damage.
University of California, Riverside (2006, August 29). Sunscreens can damage skin, researchers find. ScienceDaily. www.sciencedaily.com.
University of Illinois at Urbana-Champaign (2001, Sept 3).Study shows antioxidants play vital role in protecting skin. ScienceDaily. www.sciencedaily.com.
The horribly painful affliction of gout has been with humankind for thousands of years. The ancient Egyptians and Greeks suffered from it. British royalty suffered from it. Perhaps your father or grandfather suffered as well. Gout primarily affects older men and has stayed at a relatively stable level in that population—until the last 30 years. Doctors and scientists are alarmed at the increasing prevalence of gout worldwide. In the United States the incidence of gout more than doubled from 1977 to 1996. In the United Kingdom, gout increased three fold from the 1970s to the 1990s. These are the latest data available. Gout may have increased even more in the last ten years.
There are several causes for this dramatic increase that puts many more people—especially older men and post-menopausal women—at risk for gout. Knowing the new causes for gout will help you take steps to prevent getting it. If you have gout, or know someone who does, this report gives you the latest news about natural prevention and treatments. Warning: The latest research reveals that you may be drinking a common beverage every day that dramatically increases your risk of gout—and all major chronic diseases. Please read this report carefully.
A new blood screening technique has turned up antibodies with the ability to neutralize many strains of the AIDS virus, a discovery that might help create a long- sought vaccine against the deadly disease.
The finding, published today in the journal Science is the result of an global effort by AIDS researchers using new methods developed by two companies, Monogram Biosciences, a unit of Laboratory Corp. of America Holdings, and closely held Theraclone Sciences of Seattle. Scientists searched the blood of HIV-infected people who were symptom-free for three years.
For the full article go to http://www.bloomberg.com
There’s a new study that suggests drinking a single large glass of wine or a tanker of beer a day may increase the risk of developing bowel cancer by around 10%.
The same study also suggests drinking around two large tankers of beer or about two large glasses of wine may increase the risk of bowel cancer by as much as 25%.
According to statistics about 35,000 new cases of bowel cancer are being diagnosed every year in Great Britain, and almost 16,100 people die from this virulent form of cancer.
Meanwhile, almost 480,000 people across 10 European countries were questioned about their drinking habits as part of the ongoing European Prospective Investigation into Cancer and Nutrition (EPIC) study.
That research is funded by Cancer Research UK, the Medical Research Council and other European agencies.
The findings on bowel cancer, published online in the International Journal of Cancer, found that people who drank 15 grams of alcohol a day – equivalent to about two units – had around a 10% increased risk of bowel cancer.
Those who drank more than 30 grams of alcohol – equivalent to three to four units – increased their bowel cancer risk by around 25%.
In the United Kingdom, one unit equates to eight grams of pure alcohol.
But the number of units a drink contains depends on how strong it is and how large the measure.
All the participants in the study were followed for a period of six years. During that period, 1,833 people developed bowel cancer.
Professor Tim Key, Cancer Research UK Epidemiologist and Deputy Director of the Cancer Epidemiology Unit in Oxford, said: “The research shows quite clearly that the more alcohol you drink the greater your risk of bowel cancer.
“The increase in risk is not large but it is important that people understand they can reduce their risk of a number of different cancers – including bowel cancer – by cutting down on alcohol.”
Dr. Lesley Walker, Cancer Research UK’s Director of Cancer Information, said: “There is a lot of confusion over safe levels of drinking.
“This partly arises over the increasing strength of some wines and beers and the fact that many pubs offer a large glass of wine that is actually equivalent to one third of a bottle.
“It is important that people do not automatically equate one drink with one unit.
“A large glass of wine with a high alcohol volume is likely to be the equivalent of considerably more than that.
“Cancer Research UK recommends that women should drink less than two units a day and men less than three.
“While there is increasing evidence that over indulging in alcohol can increase the risk of some cancers, research also shows that by far the biggest risk for life threatening diseases is the combination of smoking together with drinking alcohol.”
The British government actually recommends that men drink no more than three to four units of alcohol per day and women drink no more than two to three.
Pregnant women and those trying to conceive are ALWAYS told to avoid drinking altogether.