Resveratrol May Inhibit Inherited Breast Cancer

A new study by the National Institutes of Health reveals that a key antioxidant contained in red wine, resveratrol may provide a defense against inherited breast cancer.

Investigators from the National Institutes of Health looked for the method by which mutations in tumor suppressor genes such as BRCA-1 lead to breast cancer. They found the normal form of BRCA-1 helps maintain the expression of a protein called SIRT1. SIRT1 in turn inhibits the expression of Survivin, an apoptosis inhibitor suspected of maintaining tumors and helping them grow. However, when BRCA-1 is mutated, SIRT1 levels drop, allowing Survivin to increase.

The researchers found resveratrol, a key component of red wine and grapes, strongly inhibits the growth of BRCA-1 mutant tumors in both cultured cells and animal models. The compound wards off the cancers by enhancing the activities of SIRT1, thus reducing the expression of the cancer booster, Survivin.

Resveratrol may serve as an excellent compound for targeted therapy for BRCA1 associated breast cancers,” study author Dr. Chu-Xia Deng was quoted as saying.

SOURCE: Molecular Cell, published online October 9, 2008

Article

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

Rui-Hong Wang,1 Yin Zheng,1 Hyun-Seok Kim,1 Xiaoling Xu,1 Liu Cao,1 Tyler Luhasen,1 Mi-Hye Lee,1 Cuiying Xiao,1 Athanassios Vassilopoulos,1 Weiping Chen,2 Kevin Gardner,3 Yan-Gao Man,5 Mien Chie Hung,6 Toren Finkel,4 and Chu-Xia Deng1,

1 Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA

2 Microarray Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA

3 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA

4 Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA

5 Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA

6 Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA

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