Hidden Data Reveals Antidepressant Medications Don’t Work and May Make You Impotent

Many men who take the “new-generation” of antidepressants like Prozac (SSRIs) know first hand that they lower libido and increase impotence. Yet, that’s what their doctor told them to take for depression. And they felt better, so they kept taking them—even though there were serious side effects like impotence and loss of sex drive. Now, researchers who were able to review research trials that were never published by the pharmaceutical companies say that people feel just as good on placebo as they do on Prozac.[1]

Forty million people take Prozac and other similar drugs to beat the blues. They spend tens of billions of dollars for relief from depression. The latest research shows that placebo pills worked just as well. Dr. I. Kirsch and his research team had access to data that had not been previously published by requesting all trials through the Freedom of Information Act.

Dr. Kirsch, the lead author of the review, says, “Given these results, there seems little reason to prescribe antidepressant medication to any but the most severely depressed patients, unless alternative treatments have failed.”[2]

Meanwhile, studies are showing that natural alternatives like St. John’s wort and gingko beat the blues and anxiety better than placebo.[3] A study in the Journal of Psychiatric Research showed that older people taking gingko had significantly less anxiety than placebo groups.[4]

Warning: Do NOT go off antidepressants and anti-anxiety medications without medical supervision. There can be severe side effects.

Erectile Dysfunction and Heart Are Vitally Linked

Many of the medications that are linked to impotence are heart medications. In order to protect your heart and maintain potency as you age, you must keep your arteries, veins and capillaries in good shape. For those of you who are serious about staying off heart medications, I recommend my book A Cardiologist’s Guide to Anti-Aging, Antioxidants and Resveratrol.

Hundreds of Meds Can Make You Impotent

Over 200 medications account for an estimated 25 percent of all cases of impotency. If you have erectile dysfunction, the first thing to do is review your medications with your doctor. There may be safer alternatives without the side effect of impotency. Doctors now realize that erectile dysfunction is not a psychological problem, but a physical one. The following drugs are some of the medications that commonly cause erectile dysfunction.[5]

Antidepressant and other psychiatric medications: [6]

Amitriptyline (Elavil)

Buspirone (Buspar)

Chlordiazepoxide (Librium)

Chlorpromazine (Thorazine)

Citalopram (Celexa)

Clorazepate (Tranxene)

Desipramine (Norpramin)

Diazepam (Valium)

Doxepin (Sinequan)

Duloxetine (Cymbalta)

Escitalopram (Lexapro)

Fluoxetine (Prozac)

Fluphenazine (Prolixin)

Fluvoxamine (formerly sold as Luvox)

Imipramine (Tofranil)

Lorazepam (Ativan)

Meprobamate (Equanil)

Mesoridazine (Serentil)

Mirtazapine (Remeron)

Nefazodone (formerly Serzone)

Nortriptyline (Pamelor)

Oxazepam (Serax)

Paroxetine (Paxil)

Phenelzine (Nardil)

Phenytoin (Dilantin)

Sertraline (Zoloft)

Thioridazine (Mellaril)

Thiothixene (Navane)

Trazodone (formerly Desyrel)

Tranylcypromine (Parnate)

Trifluoperazine (Stelazine)

Venlafaxine (Effexor)

Antihistamine medications:

Dimenhydrinate (Dramamine)

Diphenhydramine (Benadryl)

Hydroxyzine (Vistaril)

Meclizine (Antivert)

Promethazine (Phenergan)

Antihypertensive and diuretic medications:

Atenolol (Tenormin)


Chlorothiazide (Diuril)

Chlorthalidone (Hygroton)

Clonidine (Catapres)

Enalapril (Vasotec)

Guanabenz (Wytensin)

Guanethidine (Ismelin)

Guanfacine (Tenex)

Haloperidol (Haldol)

Hydralazine (Apresoline)

Hydrochlorothiazide (Esidrix)

Labetalol (Normodyne)

Methyldopa (Aldomet)

Metoprolol (Lopressor)

Minoxidil (Loniten)

Phenoxybenzamine (Dibenzyline)

Phentolamine (Regitine)

Prazosin (Minipress)

Propranolol (Inderal)

Reserpine (Serpasil)

Spironolactone (Aldactone)

Triamterene (Maxzide)

Verapamil (Calan)

Among the anti-hypertensive medications, thiazides are the most common cause of ED, followed by beta-blockers. Alpha-blockers are, in general, less likely to cause this problem.

Parkinson’s disease medications:

Benztropine (Cogentin)

Biperiden (Akineton)

Bromocriptine (Parlodel)

Levodopa (Sinemet)

Procyclidine (Kemadrin)

Trihexyphenidyl (Artane)

Chemotherapy medications:

Antiandrogens (Casodex, Flutamide, Nilutamide)

Busulfan (Myleran)

Cyclophosphamide (Cytoxan)


LHRH agonists (Lupron, Zoladex)

Other medications:

Aminocaproic acid (Amicar)


Clofibrate (Atromid-S)

Cyclobenzaprine (Flexeril)


Digoxin (Lanoxin)

Disopyramide (Norpace)


Finasteride (Propecia, Proscar)

Furazolidone (Furoxone)

H2 Blockers (Tagamet, Zantac, Pepcid)

Indomethacin (Indocin)

Lipid lowering-agents

Metoclopramide (Reglan)

NSAIDs (Ibuprofen, etc.)

Orphenadrine (Norflex)

Prochlorperazine (Compazine)

Opiate analgesics (painkillers)



Fentanyl (Innovar)

Meperidine (Demerol)


Oxycodone (Oxycontin, Percodan)

Hydromorphone (Dilaudid)

Recreational Drugs:








Statins and Fibrates[7]










Men—Defend Your Potency!

It’s time to realize that the epidemic of impotency in this country has many causes that you may not know about. Medications, excessive alcohol, smoking, lack of exercise, junk food and sodas with fructose corn syrup and trans fats that cause inflammation and oxidation, stress, lack of sleep, depression and anxiety are all causes of impotency that can be prevented or treated with dietary supplements, healthy foods and lifestyle changes. You do not have to give up satisfying sexual relationships as you age. You do have to make choices and take action to defend your potency.


[1] Kirsch (2008).

[2] Boseley S. Prozac, used by 40 million people, does not work, say scientists. The Guardian. Available from: www.guardian.co.uk.

[3] Kasper S, et al. Superior efficacy of St John’s wort extract Ws® 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial. BMC Med. 2006;4:14. Available from: http://www.biomedcentral.com/1741-7015/4/14.

[4] Woelk H. Ginkgo biloba special extract EGb 761® in generalized anxiety disorder and adjustment disorder with anxious mood: A randomized, double-blind, placebo-controlled trial. J Psych Res. 2007 Sep;41(6):472-80.

[5] Health Central. Drugs that may cause impotence. Available from: http://www.healthcentral.com/erectile-dysfunction/medications-8782-108_pf.html

[6] Medical News Today. Newer class of antidepressants similar in effectiveness, side effects differ. 29 Jan 2007. Available from: http://www.medicalnewstoday.com/articles/61811.php.

[7] Rizvi K, et al. Do lipid-lowering drugs cause erectile dysfunction? A systematic review. Fam Prac. 2002;19(1):95-98.

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